Fields Laboratory for Orthopaedic Biomechanics and Biotransport

Our work

Aaron Fields, PhD and his lab are performing broad research related to structure-function relationships in musculoskeletal tissues, with a particular focus on the mechanisms of nutrient transport in bone and cartilage and harnessing nutrient transport for tissue repair and regeneration. The lab combines engineering and biology approaches for (1) understanding the effects of aging and disease on structure-transport relationships and (2) developing translatable diagnostic and therapeutic strategies. An overall theme of this work is the use of advanced experimental and computational tools to measure how tissue constituents at the nano- and microscales impact whole-organ behavior.

Current projects

Our lab's current projects include:

  • Developing diagnostic tools for assessing endplate permeability and therapies for enhancing endplate permeability
  • Understanding of the role of lacunar-canalicular system permeability in osteonecrosis of the femoral head
  • Discovering the nanonscale and microscale contributors to diabetic skeletal fragility