Publications

Low back pain patients with Modic type 1 changes exhibit distinct bacterial and non-bacterial subtypes.
Heggli I, Mengis T, Laux CJ, Opitz L, Herger N, Menghini D, Schuepbach R, Farshad-Amacker NA, Brunner F, Fields AJ, Farshad M, Distler O, Dudli S Osteoarthritis and cartilage open, 2024

[Evidence-based interventions to treat chronic low back pain: treatment selection for a personalized medicine approach : German version].
Mauck MC, Aylward AF, Barton CE, Birckhead B, Carey T, Dalton DM, Fields AJ, Fritz J, Hassett AL, Hoffmeyer A, Jones SB, McLean SA, Mehling WE, O'Neill CW, Schneider MJ, Williams DA, Zheng P, Wasan AD Schmerz (Berlin, Germany), 2024

Impact of the COVID-19 pandemic on the productivity and career prospects of musculoskeletal researchers.
Chakraborty LS, Le Maitre CL, Chahine NO, Fields AJ, Gawri R, Giers MB, Smith LJ, Tang SY, Zehra U, Haglund L, Samartzis D, Martin JT Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2024

Design of the COMEBACK and BACKHOME Studies, Longitudinal Cohorts for Comprehensive Deep Phenotyping of Adults with Chronic Low-Back Pain (cLBP): a part of the BACPAC Research Program.
Hue TF, Lotz JC, Zheng P, Black DM, Bailey J, Ewing SK, Fields AJ, Mehling W, Scheffler A, Strigo I, Petterson T, Wu LA, O'Neill C, UCSF REACH Center, the CoRe CEnter for PAtient-Centric Mechanistic PHenotyping in Chronic Low Back P medRxiv : the preprint server for health sciences, 2024

4. Systematic clustering analysis using multimodal data in a chronic low back pain cohort: a preliminary baseline analysis in the ComeBACK Study.
Itsunori Watanabe, Aaron J. Fields, Wolf Mehling, Anastasia Keller, Robert Matthew, Jeannie F Bailey, Paul Anderson, Sachin Umrao, Naoki Takegami, Yoshihito Imagawa, Trisha Hue, Jeffrey C. Lotz, Thomas Andrew Peterson, Adam Ferguson, Abel Torres Espin North American Spine Society Journal (NASSJ), 2024

Deep-learning-based biomarker of spinal cartilage endplate health using ultra-short echo time magnetic resonance imaging.
Noah B. Bonnheim, Linshanshan Wang, Ann A. Lazar, Ravi Chachad, Jiamin Zhou, Xiaojie Guo, Conor O’Neill, Joel Castellanos, Jiang Du, Hyungseok Jang, Roland Krug, Aaron J. Fields Quantitative Imaging in Medicine and Surgery, 2023

Bullying, harassment, and discrimination of musculoskeletal researchers and the impact of the COVID-19 pandemic: an international study.
Martin JT, Asimakopoulos D, Hornung AL, Toro SJ, Le Maitre CL, Chahine NO, Fields AJ, Gawri R, Giers MB, Smith LJ, Tang SY, Zehra U, Haglund L, Samartzis D European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2023

Deep-learning-based biomarker of spinal cartilage endplate health using ultra-short echo time magnetic resonance imaging.
Bonnheim NB, Wang L, Lazar AA, Chachad R, Zhou J, Guo X, O'Neill C, Castellanos J, Du J, Jang H, Krug R, Fields AJ Quantitative Imaging in Medicine and Surgery, 2023

Non-enzymatic glycation reduces glucose transport in the human cartilage endplate independently of matrix porosity or proteoglycan content.
Jae-Young Jung, Mohamed Habib, Luke J. Morrissette, Shannon C. Timmons, Tristan Maerz, Aaron J. Fields JOR spine, 2023

Type 2 diabetes impairs annulus fibrosus fiber deformation and rotation under disc compression in the UCD-T2DM rat model.
James L Rosenberg, Eric Schaible, Alan Bostrom, Ann A Lazar, James L Graham, Kimber L Stanhope, Robert O Ritchie, Tamara N Alliston, Jeffrey C Lotz, Peter J Havel, Claire Acevedo, Aaron J Fields PNAS Nexus, 2023

Type 2 diabetes impairs annulus fibrosus fiber deformation and rotation under disc compression in the University of California Davis type 2 diabetes mellitus (UCD-T2DM) rat model.
Rosenberg JL, Schaible E, Bostrom A, Lazar AA, Graham JL, Stanhope KL, Ritchie RO, Alliston TN, Lotz JC, Havel PJ, Acevedo C, Fields AJ PNAS Nexus, 2023

UTE-MRI for Spinal Applications.
Noah B. Bonnheim, Misung Han, Aaron J. Fields, Cynthia Chin, Roland Krug MRI of Short and Ultrashort-T_2 Tissues, 2023

The Back Pain Consortium (BACPAC) Research Program: Structure, Research Priorities, and Methods.
Mauck MC, Lotz J, Psioda MA, Carey TS, Clauw DJ, Majumdar S, Marras WS, Vo N, Aylward A, Hoffmeyer A, Zheng P, Ivanova A, McCumber M, Carson C, Anstrom KJ, Bowden AE, Dalton D, Derr L, Dufour J, Fields AJ, Fritz J, Hassett AL, Harte SE, Hue TF, Krug R, Loggia ML, Mageswaran P, McLean SA, Mitchell UH, O'Neill C, Pedoia V, Quirk DA, Rhon DI, Rieke V, Shah L, Sowa G, Spiegel B, Wasan AD, Wey HM, LaVange L Pain medicine (Malden, Mass.), 2023

The BACPAC Research Program Data Harmonization: Rationale for Data Elements and Standards.
Batorsky A, Bowden AE, Darwin J, Fields AJ, Greco CM, Harris RE, Hue TF, Kakyomya J, Mehling W, O'Neill C, Patterson CG, Piva SR, Sollmann N, Toups V, Wasan AD, Wasserman R, Williams DA, Vo NV, Psioda MA, McCumber M Pain medicine (Malden, Mass.), 2023

ISSLS Prize in Bioengineering Science 2023: Age- and sex-related differences in lumbar intervertebral disc degeneration between patients with chronic low back pain and asymptomatic controls.
Bonnheim NB, Lazar AA, Kumar A, Akkaya Z, Zhou J, Guo X, O'Neill C, Link TM, Lotz JC, Krug R, Fields AJ European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2023

Intradiscal treatment of the cartilage endplate for improving solute transport and disc nutrition.
Habib M, Hussien S, Jeon O, Lotz JC, Wu PI, Alsberg E, Fields AJ Frontiers in bioengineering and biotechnology, 2023

Paraspinal Muscle in Chronic Low Back Pain: Comparison Between Standard Parameters and Chemical Shift Encoding-Based Water-Fat MRI.
Sollmann N, Bonnheim NB, Joseph GB, Chachad R, Zhou J, Akkaya Z, Pirmoazen AM, Bailey JF, Guo X, Lazar AA, Link TM, Fields AJ, Krug R Journal of magnetic resonance imaging : JMRI, 2022

Using hierarchical unsupervised learning to integrate and reduce multi-level and multi-paraspinal muscle MRI data in relation to low back pain.
Torres-Espin A, Keller A, Johnson GTA, Fields AJ, Krug R, Ferguson AR, Hargens AR, O'Neill CW, Lotz JC, Bailey JF European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2022

The contributions of cartilage endplate composition and vertebral bone marrow fat to intervertebral disc degeneration in patients with chronic low back pain.
Bonnheim NB, Wang L, Lazar AA, Zhou J, Chachad R, Sollmann N, Guo X, Iriondo C, O'Neill C, Lotz JC, Link TM, Krug R, Fields AJ European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2022

Spatial distribution of fat infiltration within the paraspinal muscles: implications for chronic low back pain.
Khattab K, Dziesinski LK, Crawford R, Ballatori A, Nyayapati P, Krug R, Fields A, O'Neill CW, Lotz JC, Bailey JF European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2022

Magnetic resonance imaging of the lumbar spine-recommendations for acquisition and image evaluation from the BACPAC Spine Imaging Working Group.
Sollmann N, Fields AJ, O'Neill C, Nardo L, Majumdar S, Chin CT, Tosun D, Han M, Vu AT, Ozhinsky E, Shah LM, Harris RE, Lobo R, Anderst W, Herzog R, Psioda MA, Standaert CJ, Price RT, Lotz JC, Link TM, Krug R Pain medicine (Malden, Mass.), 2022

Evidence-based interventions to treat chronic low back pain: treatment selection for a personalized medicine approach.
Mauck MC, Aylward AF, Barton CE, Birckhead B, Carey T, Dalton DM, Fields AJ, Fritz J, Hassett AL, Hoffmeyer A, Jones SB, McLean SA, Mehling WE, O'Neill CW, Schneider MJ, Williams DA, Zheng P, Wasan AD Pain reports, 2022

Influence of patient-specific factors when comparing multifidus fat infiltration between chronic low back pain patients and asymptomatic controls.
Alexander M. Ballatori, Shane Shahrestani, Priya Nyayapati, Vibhu Agarwal, Roland Krug, Misung Han, Aaron J. Fields, Conor O'Neill, Sibel Demir-Deviren, Jeffrey C. Lotz, Jeannie F. Bailey JOR spine, 2022

Protocol for Biospecimen Collection and Analysis within the BACPAC Research Program.
Fields AJ, Dudli S, Schrepf A, Kim A, Pham B, Gallego E, Mendoza S, Meropol SB, Darwin J, Sowa G, Vo NV Pain medicine (Malden, Mass.), 2022

Influence of patient-specific factors when comparing multifidus fat infiltration between chronic low back pain patients and asymptomatic controls.
Ballatori AM, Shahrestani S, Nyayapati P, Agarwal V, Krug R, Han M, Fields AJ, O'Neill C, Demir-Deviren S, Lotz JC, Bailey JF JOR spine, 2022

Measurement of vertebral endplate bone marrow lesion (Modic change) composition with water-fat MRI and relationship to patient-reported outcome measures.
Fields AJ, Ballatori A, Han M, Bailey JF, McCormick ZL, O'Neill CW, Demir-Deviren S, Krug R, Lotz JC European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2021

Development of a standardized histopathology scoring system for human intervertebral disc degeneration: an Orthopaedic Research Society Spine Section Initiative.
Le Maitre CL, Dahia CL, Giers M, Illien-Junger S, Cicione C, Samartzis D, Vadala G, Fields A, Lotz J JOR spine, 2021

Non-enzymatic glycation of annulus fibrosus alters tissue-level failure mechanics in tension.
Werbner B, Lee M, Lee A, Yang L, Habib M, Fields AJ, O'Connell GD Journal of the mechanical behavior of biomedical materials, 2021

Serum Biomarkers for Connective Tissue and Basement Membrane Remodeling are Associated with Vertebral Endplate Bone Marrow Lesions as Seen on MRI (Modic Changes).
Dudli S, Ballatori A, Bay-Jensen AC, McCormick ZL, O'Neill CW, Demir-Deviren S, Krug R, Heggli I, Juengel A, Karppinen J, Brunner F, Farshad M, Distler O, Lotz JC, Fields AJ International journal of molecular sciences, 2020

Evaluation of human cartilage endplate composition using MRI: spatial variation, association with adjacent disc degeneration, and in vivo repeatability.
Wang L, Han M, Wong J, Zheng P, Lazar AA, Krug R, Fields AJ Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2020

Automatic Vertebral Body Segmentation Based on Deep Learning of Dixon Images for Bone Marrow Fat Fraction Quantification.
Zhou J, Damasceno PF, Chachad R, Cheung JR, Ballatori A, Lotz JC, Lazar AA, Link TM, Fields AJ, Krug R Frontiers in endocrinology, 2020

Osteocyte dysfunction promotes osteoarthritis through MMP13-dependent suppression of subchondral bone homeostasis.
Mazur CM, Woo JJ, Yee CS, Fields AJ, Acevedo C, Bailey KN, Kaya S, Fowler TW, Lotz JC, Dang A, Kuo AC, Vail TP, Alliston T Bone research, 2019

Associations between vertebral body fat fraction and intervertebral disc biochemical composition as assessed by quantitative MRI.
Roland Krug, Gabrielle B. Joseph, Misung Han, Aaron Fields, Justin Cheung, Maya Mundada, Jeannie Bailey, Alice Rochette, Alexander Ballatori, Charles E. McCulloch, Zachary McCormick, Conor O'Neill, Thomas M. Link, Jeffrey Lotz Journal of Magnetic Resonance Imaging, 2019

Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones.
Herber CB, Krause WC, Wang L, Bayrer JR, Li A, Schmitz M, Fields A, Ford B, Zhang Z, Reid MS, Nomura DK, Nissenson RA, Correa SM, Ingraham HA , 2019

Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones.
Herber CB, Krause WC, Wang L, Bayrer JR, Li A, Schmitz M, Fields A, Ford B, Zhang Z, Reid MS, Nomura DK, Nissenson RA, Correa SM, Ingraham HA Nature communications, 2019

Associations between vertebral body fat fraction and intervertebral disc biochemical composition as assessed by quantitative MRI.
Krug R, Joseph GB, Han M, Fields A, Cheung J, Mundada M, Bailey J, Rochette A, Ballatori A, McCulloch CE, McCormick Z, O'Neill C, Link TM, Lotz J Journal of magnetic resonance imaging : JMRI, 2019

The Relationship Between Endplate Pathology and Patient-Reported Symptoms for Chronic Low Back Pain Depends on Lumbar Paraspinal Muscle Quality.
Bailey JF, Fields AJ, Ballatori A, Cohen D, Jain D, Coughlin D, O'Neill C, McCormick Z, Han M, Krug R, Demir-Deviren S, Lotz JC Spine, 2019

Measuring and reporting of vertebral endplate bone marrow lesions as seen on MRI (Modic changes): recommendations from the ISSLS Degenerative Spinal Phenotypes Group.
Fields AJ, Battié MC, Herzog RJ, Jarvik JG, Krug R, Link TM, Lotz JC, O'Neill CW, Sharma A European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2019

Suppressed Osteocyte Perilacunar / Canalicular Remodeling Plays a Causal Role in Osteoarthritis.
Courtney M Mazur,Jonathon J Woo,Cristal S Yee,Aaron J Fields,Claire Acevedo,Karsyn N Bailey,Tristan W Fowler,Jeffrey C Lotz,Alexis Dang,Alfred Kuo,Thomas P Vail,Tamara Alliston bioRxiv, 2019

Estrogen Signaling in Arcuate Kiss1 Neurons Suppresses a Sex-Dependent Circuit That Promotes Dense Strong Bones in Female Mice.
Candice B Herber,William C Krause,Liping Wang,James R Bayrer,Alfred Li,Matthew T Schmitz,Aaron Fields,Breanna Ford,Michelle S Reid,Daniel K Nomura,Robert A Nissenson,Stephanie M Correa,Holly A Ingraham bioRxiv, 2018

Developmental Mechanisms Linking Form and Function During Jaw Evolution.
Katherine C Woronowicz,Stephanie E Gline,Safa T Herfat,Aaron J Fields,Richard A Schneider bioRxiv, 2018

Effects of dynamic loading on solute transport through the human cartilage endplate.
Sampson SL, Sylvia M, Fields AJ Journal of biomechanics, 2018

Contribution of the endplates to disc degeneration.
Fields AJ, Ballatori A, Liebenberg EC, Lotz JC Current molecular biology reports, 2018

Cartilage Endplate Thickness Variation Measured by Ultrashort Echo-Time MRI Is Associated With Adjacent Disc Degeneration.
Berg-Johansen B, Han M, Fields AJ, Liebenberg EC, Lim BJ, Larson PE, Gunduz-Demir C, Kazakia GJ, Krug R, Lotz JC Spine, 2018

FGF and TGFβ Signaling Link Form and Function During Jaw Development and Evolution.
Woronowicz KC, Gline SE, Herfat ST, Fields AJ, Schneider RA Developmental biology, 2018

Publication trends in spine research from 2007 to 2016: Comparison of the Orthopaedic Research Society Spine Section and the International Society for the Study of the Lumbar Spine.
Martin JT, Gullbrand SE, Fields AJ, Purmessur D, Diwan AD, Oxland TR, Chiba K, Guilak F, Hoyland JA, Iatridis JC JOR spine, 2018

Larger vertebral endplate concavities cause higher failure load and work at failure under high-rate impact loading of rabbit spinal explants.
Dudli S, Enns-Bray W, Pauchard Y, Römmeler A, Fields AJ, Ferguson SJ, Helgason B Journal of the mechanical behavior of biomedical materials, 2018

Contributions of Material Properties and Structure to Increased Bone Fragility for a Given Bone Mass in the UCD-T2DM Rat Model of Type 2 Diabetes.
Acevedo C, Sylvia M, Schaible E, Graham JL, Stanhope KL, Metz LN, Gludovatz B, Schwartz AV, Ritchie RO, Alliston TN, Havel PJ, Fields AJ Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2018

Tidemark Avulsions are a Predominant Form of Endplate Irregularity.
Berg-Johansen B, Jain D, Liebenberg EC, Fields AJ, Link TM, O'Neill CW, Lotz JC Spine, 2018

Structure-function relationships at the human spinal disc-vertebra interface.
Berg-Johansen B, Fields AJ, Liebenberg EC, Li A, Lotz JC Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2017

Role of Osteoblast Gi Signaling in Age-Related Bone Loss in Female Mice.
Millard SM, Wang L, Wattanachanya L, O'Carroll D, Fields AJ, Pang J, Kazakia G, Lotz JC, Nissenson RA Endocrinology, 2017

Glucocorticoid suppression of osteocyte perilacunar remodeling is associated with subchondral bone degeneration in osteonecrosis.
Fowler TW, Acevedo C, Mazur CM, Hall-Glenn F, Fields AJ, Bale HA, Ritchie RO, Lotz JC, Vail TP, Alliston T Scientific reports, 2017

Pathobiology of Modic changes.
Dudli S, Fields AJ, Samartzis D, Karppinen J, Lotz JC European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2016

Secondary Chondrogenesis on The Coronoid Process of The Mandible Requires Both FGF And TGFß Signaling.
Katherine C Woronowicz, Danielle Z Jaul, Safa T Herfat, Aaron J Fields, Jeffrey C Lotz, Richard A Schneider The FASEB Journal, 2016

Alterations in intervertebral disc composition, matrix homeostasis and biomechanical behavior in the UCD-T2DM rat model of type 2 diabetes.
Fields AJ, Berg-Johansen B, Metz LN, Miller S, La B, Liebenberg EC, Coughlin DG, Graham JL, Stanhope KL, Havel PJ, Lotz JC Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2015

FGF and TGFß Signaling are Required During Secondary Chondrogenesis in the Jaw Skeleton.
Katherine Woronowicz, Danielle Jaul, Safa Herfat, Aaron Fields, Jeffrey Lotz, Richard Schneider The FASEB Journal, 2015

Trabecular plates and rods determine elastic modulus and yield strength of human trabecular bone.
Wang J, Zhou B, Liu XS, Fields AJ, Sanyal A, Shi X, Adams M, Keaveny TM, Guo XE Bone, 2014

Comparison of vertebral and intervertebral disc lesions in aging humans and rhesus monkeys.
Bailey JF, Fields AJ, Liebenberg E, Mattison JA, Lotz JC, Kramer PA Osteoarthritis and cartilage, 2014

Structural parameters determining the strength of the porcine vertebral body affected by tumours.
Sahli F, Cuellar J, Pérez A, Fields AJ, Campos M, Ramos-Grez J Computer methods in biomechanics and biomedical engineering, 2014

Influence of biochemical composition on endplate cartilage tensile properties in the human lumbar spine.
Fields AJ, Rodriguez D, Gary KN, Liebenberg EC, Lotz JC Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2013

Innervation of pathologies in the lumbar vertebral end plate and intervertebral disc.
Fields AJ, Liebenberg EC, Lotz JC The spine journal : official journal of the North American Spine Society, 2013

The role of the vertebral end plate in low back pain.
Lotz JC, Fields AJ, Liebenberg EC Global spine journal, 2013

Individual Trabecula Segmentation (ITS)-Based Plate-Rod Microstructural Finite Element Model Predicts Nonlinear Mechanical Properties of Human Trabecular Bone.
Bin Zhou,Ji Wang,Arnav Sanyal,Aaron J. Fields,Hong Wang,Tony M. Keaveny,Baohua Ji,X. Sherry Liu,X. Edward Guo , 2012

Vertebral fragility and structural redundancy.
Fields AJ, Nawathe S, Eswaran SK, Jekir MG, Adams MF, Papadopoulos P, Keaveny TM Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2012

Micromechanics of the human vertebral body for forward flexion.
Yang H, Nawathe S, Fields AJ, Keaveny TM Journal of biomechanics, 2012

Trabecular architecture and vertebral fragility in osteoporosis.
Fields AJ, Keaveny TM Current osteoporosis reports, 2012

Bone Biomechanical Behavior in Adult Mice is Regulated by Osteoblast Gi Signaling in a Sex- and Site-Specific Manner.
Aaron J. Fields,Susan M. Millard,Jeannie F. Bailey,Dylan O’Carroll,Jeffrey C. Lotz,Robert A. Nissenson , 2011

Influence of vertical trabeculae on the compressive strength of the human vertebra.
Fields AJ, Lee GL, Liu XS, Jekir MG, Guo XE, Keaveny TM Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2011

Mechanisms of initial endplate failure in the human vertebral body.
Fields AJ, Lee GL, Keaveny TM Journal of biomechanics, 2010

Role of trabecular microarchitecture in whole-vertebral body biomechanical behavior.
Fields AJ, Eswaran SK, Jekir MG, Keaveny TM Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2009

Multi-scale modeling of the human vertebral body: comparison of micro-CT based high-resolution and continuum-level models.
Eswaran SK, Fields AJ, Nagarathnam P, Keaveny TM Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing, 2009

Effects of knee simulator loading and alignment variability on predicted implant mechanics: a probabilistic study.
Laz PJ, Pal S, Fields A, Petrella AJ, Rullkoetter PJ Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2006

Neck and shoulder pain.
FIELDS A, HOESLEY J California medicine, 1949